A family is attacked by demons and only two members survive - Tanjiro and his sister Nezuko, who is turning into a demon slowly. Tanjiro sets out to become a demon slayer to avenge his family and cure his sister.

A boy swallows a cursed talisman - the finger of a demon - and becomes cursed himself. He enters a shaman's school to be able to locate the demon's other body parts and thus exorcise himself.